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Vepdegestrant (ARV-471)

An investigational, oral PROTAC® estrogen receptor (ER) degrader.

Vepdegestrant is currently under investigation. Its safety and effectiveness have not been established.

Vepdegestrant is being co-developed with Pfizer.

Clinical Trial Information

VERITAC-2 (C4891001)
Phase 3
Vepdegestrant vs fulvestrant in previously treated ER+/HER- advanced or metastatic breast cancer
VERITAC-3 (C4891002)
Phase 3
Vepdegestrant plus palbociclib vs letrozole plus palbociclib in previously untreated ER+/HER- advanced breast cancer
TACTIVE-U (C4891006)
Phase 1b/2
An umbrella study of vepdegestrant plus other anticancer therapies in ER+ advanced or metastatic breast cancer
Sub-study A – Vepdegestrant plus abemaciclib
Sub-study B – Vepdegestrant plus ribociclib
TACTIVE-K
Phase 1b/2
A phase 1b/2 open-label study of vepdegestrant (ARV-471) in combination with PF-07220060 (a CDK4 inhibitor) in patients with ER+/HER2- advanced or metastatic breast cancer
ARV-471-mBC-101
Phase 1/2
Vepdegestrant +/- palbociclib in ER+/HER2- advanced or metastatic breast cancer
A Phase 1b/2 Open-Label Study of Vepdegestrant (ARV-471) in Combination With PF-07220060 (a CDK4 Inhibitor) in Patients With ER+/HER2- Advanced or Metastatic Breast Cancer
Phase 1b/2
Vepdegestrant + PF-07220060 (a CDK4 inhibitor) ER+/HER2- advanced or metastatic breast cancer

Mechanism of Action

Proposed MOA of Vepdegestrant

Program Resources

Learn how the proposed MOA of Vepdegestrant differs from the MOA of SERDs

Related Links

Vepdegestrant Congress Presentations

Access materials related to Vepdegestrant presentations at scientific congresses.

Vepdegestrant Publications

View Arvinas publications about Vepdegestrant.

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