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Vepdegestrant (ARV-471)

An investigational, oral PROTAC® estrogen receptor (ER) degrader.

Vepdegestrant is currently under investigation. Its safety and effectiveness have not been established.

Vepdegestrant is being co-developed with Pfizer.

Clinical Trial Information

Phase 3
Vepdegestrant vs fulvestrant in previously treated ER+/HER- advanced or metastatic breast cancer
Phase 3
Vepdegestrant plus palbociclib vs letrozole plus palbociclib in previously untreated ER+/HER- advanced breast cancer
Phase 1b/2
An umbrella study of vepdegestrant plus other anticancer therapies in ER+ advanced or metastatic breast cancer
Sub-study A – Vepdegestrant plus abemaciclib
Sub-study B – Vepdegestrant plus ribociclib
Sub-study C – Vepdegestrant plus samuraciclib
Phase 1b/2
A phase 1b/2 open-label study of vepdegestrant (ARV-471) in combination with PF-07220060 (a CDK4 inhibitor) in patients with ER+/HER2- advanced or metastatic breast cancer
Phase 2
A phase 2 neoadjuvant study evaluating ARV-471 or anastrozole in post-menopausal women with ER+/HER2- localized breast cancer
Phase 1b
A phase 1b study to assess the combination of ARV-471 and everolimus in participants with advanced or metastatic ER+/HER2- breast cancer
Phase 1/2
Vepdegestrant alone or in combination with palbociclib in ER+/HER2- advanced or metastatic breast cancer

Mechanism of Action

Proposed MOA of vepdegestrant

Program Resources

Learn how the proposed MOA of vepdegestrant differs from the MOA of SERDs

Related Links

Vepdegestrant Congress Presentations

Access materials related to vepdegestrant presentations at scientific congresses.

Vepdegestrant Publications

View Arvinas publications about vepdegestrant.

Contact My MSL

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Arvinas Oncology Medical

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Arvinas Oncology Medical

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